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  • 21 juinMatrix metalloproteinase 11, a key player in adipocye-cancer cell crosstalk

    21 juin 2013
    Séminaires/Colloques

     

    Marie-Christine RIO

    Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGMC),
    CNRS UMR 7104, INSERM U964, Université de Strasbourg, Ilkirch

    Invitée par Catherine SAUTES-FRIDMAN

    Matrix metalloproteinase 11, a key player in adipocye-cancer cell crosstalk

     

    Texte en anglais

    It is well admitted that tumor microenvironment is crucial for cancer progression. In this context, matrix metalloproteinase 11 (MMP-11) represents a paracrine factor of bad prognosis in almost all human invasive cracinomas. Our studies bring evidence that MMP-11 negatively controls adipogenesis by limiting pre-adipocyte differentiation and/or reversing mature adipocyte differentiation, and that this function is aberrantly restored following adipocyte-cancer cell cross-talk during invasive processes. Collectively, these data strongly support the concept that adipocytes play an important role during tumor progression, and highlight the essential function of MMP-11 in this process. They are of particular interest since obesity is a worldwide health problem and epidemiological studies identify obesity as a poor prognosis factor for several cancers.

     

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