24 maiMyeloid derived suppressor cells their role and regulation in cancer24 mai 2013
Head of Team 1 INSERM 866 "Chemotherapy, lipid metabolim and immune response"
Full Professor of Oncology, University of Burgundy, Department odf Medical Oncology, Dijon
Invité par Catherine Sautès-Fridman
« Myeloid derived suppressor cells their role and regulation in cancer »
Myeloid-Derived Suppressor Cells (MDSC) are a population of immature myeloid cells, which could suppress T dependent immune response. MDSC numbers increase inblood and lymphoid organ of mice and human bearing tumor. Thus, a cytotoxic drug that electively eliminates MDSC while preserving T cells subset may enhance latent tumor immunity and tumor vaccine efficacy. In a recent work we describe the capacity of 5-Fluorouracil (5-FU) to eliminate MDSC. However we have also discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting TH17 responses that compromise anticancer immunity. This underscores the need to combine 5-FU with NLRP3 inhibitors to prevent tumor progression.
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