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Programme des Séminaires du CRC

Séminaires de JANVIER 2013

Sauf indications, les séminaires du Centre de Recherche des Cordeliers ont lieu au, 15 rue de l’Ecole de Médecine, Paris 75006,  à 12h

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Vendredi 11 Janvier 2013 à l’amphithéatre Farabeuf

Eric SOLARY

Institut Gustave Roussy, Villejuif

 

Clonal architecture in chronic myelomonocytic leukemia

Genomic studies in chronic myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and MPN/MDS, have identified common mutations in genes encoding signaling, epigenetic, transcription and splicing factors. We interrogated the clonal architecture by mutation-specific discrimination analysis of single-cell-derived colonies in patients with chronic myelomonocytic leukemias (CMML), the most frequent MPN/MDS. This analysis reveals a linear acquisition of the  studied mutations with limited branching through loss of heterozygosity. Serial analysis of untreated and treated samples demonstrates a dynamic architecture on which most current therapeutic approaches have limited effects. The main disease characteristics are early clonal dominance, arising at the CD34+/CD38- stage of hematopoiesis, and granulomonocytic differentiation skewing of multipotent and common myeloid progenitors. Comparison of clonal expansions of TET2 mutations in MDS, MPN and CMML, together with functional invalidation of TET2 in sorted progenitors, suggests a causative link between early clonal dominance and skewed granulomonocytic differentiation. Altogether, early clonal dominance may distinguish CMML from other chronic myeloid neoplasms with similar gene mutations.

Invité par Brigitte Bauvois

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Vendredi 18 Janvier 2013 à l’amphithéatre Farabeuf

SEMINAIRE EXCEPTIONNEL du CRC

et de l'European Academy of Tumor Immunology et du Labex ImmunoOnco

 

Eileen WHITE

The Cancer Institute of New Jersey, Etats Unis

 

Role of autophagy in lung cancer

Invitée par Guido KROEMER

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Vendredi 25 Janvier 2013 à l’amphithéatre Farabeuf

 

Patrick COUVREUR

UMR CNRS 8612 – Université de Paris Sud

 

Nanomedicine for overcoming resistances mechanisms

 

L'exposé traitera de l'utilisation de nanomédicaments multifonctionnels pour le ciblage des tumeurs et le traitement des infections intracellulaires. Il montrera comment il est possible de contourner certains mécanismes de résistance qui obèrent le traitement efficace de ces pathologies.

 

Invité par Aurélie EDWARDS