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Séminaires du CRC de Juin 2013


Séminaires de JUIN 2013

Sauf indications, les séminaires du Centre de Recherche des Cordeliers ont lieu au

 15 rue de l’Ecole de Médecine, Paris 75006,  à 12h



Vendredi 7, Pavillon 1 Bât. De la Surélévation

EATI Distinguished Guest lecturer



Molecular Signaling and Cell Death Unit
 Department for molecular Biomedical Research
 University of GENT – VIB - Belgium


« Role of RIPK1 and RIPK3 in various inflammatory disease models »


Invité par Guido Kroemer


Vendredi 14, amphithéatre Gustave Roussy


 « Titre à venir»

Invité par Athina Kalopissis


Vendredi 21, amphithéâtre Bilski Pasquier

Marie-Christine RIO

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U964, Université de Strasbourg, Illkirch


« Matrix metalloproteinase 11, a key player in adipocyte-cancer cell crosstalk »


It is well admitted that tumor microenvironment is crucial for cancer progression. In this context, matrix metalloproteinase 11 (MMP-11) represents a paracrine factor of bad prognosis in almost all human invasive cracinomas. Our studies bring evidence that MMP-11 negatively controls adipogenesis by limiting pre-adipocyte differentiation and/or reversing mature adipocyte differentiation, and that this function is aberrantly restored following adipocyte-cancer cell cross-talk during invasive processes. Collectively, these data strongly support the concept that adipocytes play an important role during tumor progression, and highlight the essential function of MMP-11 in this process. They are of particular interest since obesity is a worldwide health problem and epidemiological studies identify obesity as a poor prognosis factor for several cancers.


     Invitée par Catherine Sautès-Fridman


Vendredi 28, amphithéâtre Bilski Pasquier

Francesca GRANUCCI

« Mechanisms and consequences of NFAT signaling pathway activation in innate immune cells in LPS-induced inflammatory conditions »


Innate immunity is the most ancient form of response to pathogens and it relies on evolutionary conserved signaling pathways, i.e. those involving the NF-kB pathway. Nevertheless, increasing evidence suggests that factors that have appeared more recently in evolution, such as the Nuclear Factor of Activated T cell transcription factor family (NFATc), also contribute to innate immune response regulation in vertebrates. We have observed that exposure to inflammatory stimuli, such as LPS, induces the activation of NFATc factors in innate immune cells, including conventional dendritic cells (DCs), with a mechanism TLR4-independent involving instead CD14. In turn, NFAT contributes to the regulation of IL-2 production, antigen transport to the lymph nodes via the lymph and DC life cycle. These three NFAT-controlled phenomena and the consequences of their activation will be discussed.

     Invitée par Catherine Sautès-Fridman