04 avrEndothelial microparticles, a new signature of endothelial activation04 avr 2013
Cardiovascular Research Center HEGP INSERM – U970
Microparticles (MPs) are submicron membrane vesicles released in extracellular space following cell activation or apoptosis. They harbor at their surface most of the membrane-associated proteins of the cells they stem from and are characterized by the loss of plasma membrane asymmetry resulting in the exposure of phosphatidylserine on their outer leaflet MPs of different cellular origin circulate in the blood of healthy subjects and although MPs originating from endothelial cells represent a small population of plasma MPs, their levels increase in cardiovascular diseases. In addition, MPs emerge as important new biological effectors : they are capable of transferring biological information (proteins, lipids, nucleic acids) from the parent cell to remote targets, therefore influencing disease progression and repair mechanisms.
Invited by François ALHENC-GELAS
Location : Centre des Cordeliers, Amphi Gustave Roussy, 15 rue de l'école de médecine, 75006 Paris