15 févRole of HIFs (Hypoxia Inducible Factors) in iron metabolism and innate immunity15 fév 2013
ERC Starting grant 2010
Dept Endocrinology Metabolism and Cancer
Institut Cochin, INSERM U1016, CNRS UMR 8104
HIF transcription factors, central mediators of cellular adaptation to critically low oxygen levels (=hypoxia), have been largely studied for their crucial role during cancer development. We unveiled two new major roles of HIF. First, in innate immunity and infection, we demonstrated the key contributions of HIFs in regulating important immune effectors molecules. Second, we highlighted the role of HIFs in iron metabolism as critical regulators of iron absorption in the intestine and in systemic iron homeostasis by regulating the liver synthesis of the iron regulatory hormone, hepcidin.
Invited by par Armelle Leturque
Location : Amphithéâtre BILSKI-PASQUIER, 15 rue de l’Ecole de Médecine, Paris 75006 at 12pm