28 juinMechanisms and consequences of NFAT signaling pathway activation in innate immune cells in LPS-induced inflammatory conditions28 juin 2013
Invitée par Catherine Sautès-Fridman
« Mechanisms and consequences of NFAT signaling pathway activation in innate immune cells in LPS-induced inflammatory conditions »
Texte en anglais
Innate immunity is the most ancient form of response to pathogens and it relies on evolutionary conserved signaling pathways, i.e. those involving the NF-kB pathway. Nevertheless, increasing evidence suggests that factors that have appeared more recently in evolution, such as the Nuclear Factor of Activated T cell transcription factor family (NFATc), also contribute to innate immune response regulation in vertebrates. We have observed that exposure to inflammatory stimuli, such as LPS, induces the activation of NFATc factors in innate immune cells, including conventional dendritic cells (DCs), with a mechanism TLR4-independent involving instead CD14. In turn, NFAT contributes to the regulation of IL-2 production, antigen transport to the lymph nodes via the lymph and DC life cycle. These three NFAT-controlled phenomena and the consequences of their activation will be discussed.
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