01 marsHeat shock protein 72 : a panacea for disease prevention?01 mars 2013
Professor Mark FEBBRAIO
Baker IDI Heart & Diabetes Institute
Melbourne, VIC, Australia
Mark A Febbraio, Baker IDI Heart & Diabetes Institute, Melbourne, VIC, Australia
Several years ago we identified an essential role of heat shock protein (Hsp) 72 in preventing obesity-induced insulin resistance(1). We have subsequently demonstrated that Hsp72 expression plays a pivotal role in regulating skeletal muscle oxidative capacity. Moreover, in recent experiments we have demonstrated that activation of Hsp72 can preserve muscle function, slow disease progression and increase life span in muscular dystrophy(2). This presentation will discuss common pathways in these two seemingly unrelated diseases that may be regulated by the activation of Hsp72.
Supported by grants from the National Health & Medical Research Council of Australia
1. Chung, J. et. al. (2008) Proc Natl Acad Sci USA 105: 1739-1744.
2. Gehrig, S. et al. (2012) Nature 484: 384-398
Invited by Armelle LETURQUE
Location : Amphithéâtre BILSKI-PASQUIER, 15 rue de l’Ecole de Médecine, Paris 6e at 12pm