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mars 2013

  • 01 marsHeat shock protein 72 : a panacea for disease prevention?

    01 mars 2013

    Professor Mark FEBBRAIO

    Baker IDI Heart & Diabetes Institute

    Melbourne, VIC, Australia


    Mark A Febbraio, Baker IDI Heart & Diabetes Institute, Melbourne, VIC, Australia

    Several years ago we identified an essential role of heat shock protein (Hsp) 72 in preventing obesity-induced insulin resistance(1). We have subsequently demonstrated that Hsp72 expression plays a pivotal role in regulating skeletal muscle oxidative capacity. Moreover, in recent experiments we have demonstrated that activation of Hsp72 can preserve muscle function, slow disease progression and increase life span in muscular dystrophy(2). This presentation will discuss common pathways in these two seemingly unrelated diseases that may be regulated by the activation of Hsp72.

    Supported by grants from the National Health & Medical Research Council of Australia

    1.   Chung, J. et. al. (2008) Proc Natl Acad Sci USA 105: 1739-1744.

    2.   Gehrig, S. et al. (2012) Nature 484: 384-398


    Invited by Armelle LETURQUE


    Location : Amphithéâtre BILSKI-PASQUIER, 15 rue de l’Ecole de Médecine, Paris 6e at 12pm