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Séminaires du CRC de Mai 2013

Sauf indications, les séminaires du Centre de Recherche des Cordeliers ont lieu au 15 rue de l’École de Médecine, Paris 75006,  à 12h à l'amphithéatre Bilski Pasquier

sauf pour le 31 mai où il se déroulera au Pavillon 1, Bâtiment de la Surélévation


Vendredi 17 Mai



Professor of Genetic Engineering & Molecular Ophthalmology
 Glaucoma Divison, The Wilmer Eye Institute at Johns Hopkins University School of Medicine, Baltimore, Etats-Unis


« Use of high content screening to identify neuroprotective molecules for the treatment of glaucoma and the retinal degenerations »


Glaucoma and the retinal degenerative diseases are major causes of vision loss and blindness worldwide. As one approach to identify new and more effective treatment strategies for these neurodegenerative diseases, we have been using high content screening approaches with primary retinal cells to identify small molecules that promote the differentiation and survival of retinal ganglion and photoreceptor cells. Among the leads that have been identified though this screen are a number of broad spectrum kinase inhibitors that promote cell survival both in vitro and in vivo.


Invité par Jean-Luc Teillaud


Vendredi 24 Mai



Head of Team 1 INSERM 866 "Chemotherapy, lipid metabolim and immune response"
Full Professio of Oncology, University of Burgundy, Department odf Medical Oncology, Dijon


« Myeloid derived suppressor cells their role and regulation in cancer »


Myeloid-Derived Suppressor Cells (MDSC) are a population of immature myeloid cells, which could suppress T dependent immune response. MDSC numbers increase inblood and lymphoid organ of mice and human bearing tumor. Thus, a cytotoxic drug that electively eliminates MDSC while preserving T cells subset may enhance latent tumor immunity and tumor vaccine efficacy. In a recent work we describe the capacity of 5-Fluorouracil (5-FU) to eliminate MDSC. However we have also discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting TH17 responses that compromise anticancer immunity. This underscores the need to combine 5-FU with NLRP3 inhibitors to prevent tumor progression.


  Invité par Catherine Sautès-Fridman



Vendredi 31 Mai


Philippe AGHION

Economiste, Professeur à l'Université Harvard et à l'École d'économie de Paris


"Croissance et État Stratège"

A successful innovation-led economy requires, not only the investment in the knowledge economy, not only to liberalize markets, but also to reform the governance of the state to make it more strategic. While the old welfare states are not well-suited to the needs of an economy where growth is driven by frontier innovation, the minimal state advocated by neo-liberals may not be the solution either. Between these two extreme solutions, there is what we refer to as the strategic state: the state that acts primarily on the supply side of the economy and which targets its investments on the sectors or activities with higher expected growth potential. It is a state that tries to reconcile the need to invest in growth with the need to achieve budget balance. And it is a state that looks carefully at governance, both of the sectors it invests in and of itself as investor. In this respect the example of Germany or Scandinavian countries, which have reacted to past crises by implementing structural reforms, both in labor and product markets and in the organization of the state, and now show an unemployment rate lower than in many other OECD countries and growth rates close to 3%, is worth meditating.


                  Invité par Jean-Luc Teillaud